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In fact, the mechanism that causes constipation in some patients is the same one that suppresses appetite and drives weight loss

While Retatrutides comprehensive approach, including glycogen management, supports fat loss and overall health, research is still underway to fully identify its potential side effects, such as nausea, constipation, or low blood pressure

However, clinicians should maintain a broad differential diagnosis, as symptoms such as fatigue and reduced libido can result from multiple causes, including inadequate caloric intake, nutrient deficiencies (particularly vitamin D, iron, or B vitamins), sleep disturbances, depression, or other medical conditions

These subtle changes confirm the medication is working even when the scale has not moved