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Compounded tirzepatide introduces more variability, as the quality depends on the compounding pharmacy

Sources MOUNJARO (tirzepatide) Injection, for subcutaneous use (2022) Zepbound (tirzepatide) Injection, for subcutaneous use (2022) FDA News Release: FDA Approves First Medication for Obstructive Sleep Apnea (December 20, 2024) Tirzepatide Once Weekly for the Treatment of Obesity (June 4, 2022) Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity (June 21, 2024)

If additional glycemic control is needed, the dose can be increased in 2.5 mg increments every 4 weeks

Semaglutide may be a strong option for patients who respond well to GLP-1 therapy, need a more established treatment path or tolerate it better
