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Jastreboff et al., 2023 (NEJM): estudio fase 2 en adultos con obesidad sin diabetes, reduccin ponderal media de 24.2% a la semana 48 con 12 mg semanales, el mayor efecto reportado para un frmaco incretnico hasta la fecha de publicacin

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This result was replicated in a similar but larger investigation ( N = 1,735) comparing all available GLP-1RAs versus non-GLP-1RA antidiabetics, with this antidepressant association possibly correlating with changes in markers of systemic inflammation (that is, high-sensitivity C-reactive protein) 192

The pharmacy staff will process the prescription and may be able to initiate the prior authorization process

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