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However, among adults without type 2 diabetes, tirzepatide was linked to higher recorded hazards of anxiety and insomnia than semaglutide, underscoring the need for cautious monitoring.

Bridging the gap between guidelines and practice will require systemic interventions, including physician training, patient-centered care models, and devising research strategies such as national HF registries to understand and tailor therapeutic approaches from an Indian perspective.

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