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For patients with well-controlled Graves disease who are euthyroid on antithyroid medications or following definitive treatment (radioactive iodine or thyroidectomy), tirzepatide may be considered if there are appropriate indications such as type 2 diabetes or obesity (BMI 30 kg/m or 27 kg/m with weight-related comorbidities)

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Because of the cardiorenal benefits of RAASis, if these medications must be temporarily reduced or withheld due to hyperkalemia, a retrial of RAASi should be considered, potentially at a lower dose once hyperkalemia is resolved