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Eligibility criteria We included RCTs with a duration of intervention of at least 12 weeks that compared tirzepatide at a maintenance dose of 5, 10 or 15 mg once-weekly, administered subcutaneously, with placebo or any other glucose-lowering medication

It is similar enough to GLP-1 to allow it to fit into the GLP-1 receptor and act as an agonist

That means new medications can reach the market without solid data on how they affect breast milk or a nursing baby

The greatest effects on gastric motility appear to occur during treatment initiation, dose escalation phases, and higher-dose maintenance therapy

Each of the lawsuits raises similar allegations, indicating that the drug makers knew or should have known about the potential gastroparesis side effects, but placed a desire for profits above consumer safety, by withholding critical warnings and safety information from consumers and the medical community