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These consultations allow monitoring of: Glycaemic control through HbA1c measurements (usually every 36 months) Weight changes and body composition Tolerability and adverse effects , particularly gastrointestinal symptoms Blood pressure and heart rate Renal function tests NICE recommends (NG28) that GLP-1 therapy should be continued only if there is demonstrable benefittypically defined as an HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at six months for diabetes indications

Often, simple adjustments such as hydration, nutrition, and appropriate dental care products can make a significant difference." When to seek professional help While mild sensitivity or dryness may be manageable, persistent symptoms should be assessed

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Consistent with these results in isolated ventricles suggesting a role for ATP-sensitive K + channels in mediating the effects of GLP-1 during RPc, in mice with Kir6.1 knocked out in pericytes, RPc was not protective against ischaemia/reperfusion injury (Fig

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