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Ethinylestradiol/Levonorgestrel The estimated treatment ratio of AUC 0-24,SS for ethinylestradiol was 1.06 and the 90% CI (1.011.10) was within the pre-specified no effect interval

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According to PubMed, recent comprehensive reviews document effects on cardiovascular protection (reduced major adverse cardiovascular events), neuroprotection (reduced neuroinflammation, potential effects on Alzheimer's pathology), renal protection (reduced albuminuria and renal decline), hepatic improvement (reduced steatosis and fibrosis markers), adipose tissue remodeling (enhanced mitochondrial biogenesis, beige adipocyte programming, reduced visceral fat inflammation), modulation of gut microbiota composition, and even preliminary signals in obstructive sleep apnoea, substance use disorders, and tumour biology (Lu et al., 2024, DOI

"Fatty liver disease is the most frequent liver disease in adolescents with no drug therapy currently available