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It is crucial to ensure that the nanoparticles do not induce systemic toxicity or harm the overall health of the patient

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28,29 While not associated with clinical benefit in HFrEF, recently, these drugs have been studied in patients with HFpEF demonstrating improvements in clinical outcomes such as health-related quality of life (STEP-HFpEF) as well as reductions in cardiovascular death and HF events (SUMMIT)

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