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Effectiveness of surgical interventions for managing obesity in children and adolescents: a systematic review and meta-analysis framed using minimal important difference estimates based on grade guidance to inform a clinical practice guideline

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Surgery was previously the gold standard for closure of ASDs, but many defects especially secundum atrial septal defects are closed in the cath lab

A esto se suma una reduccin significativa del cido rico y de biomarcadores como el 2-aminoadipato, que suelen preceder al fallo de las clulas del pncreas