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This hypothesis is supported indirectly by evidence that both serum GLP-1 levels and GLP1R expression varies with estrous cycle phase across multiple tissues, although the specific cell types involved have not been characterized 3033

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Table 3

The central application of GLP-1 receptor agonists potently decreases food intake, likely through GLP-1 receptor (GLP-1R)-expressing targets in multiple brain areas including in the hypothalamus and brainstem (24, 26, 28-30), nuclei also targeted by estrogen (31), supporting a potential interaction