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Besides being more convenient for the patient, there seem to be added benefits of creating a more stable pharmacodynamics profile (i.e., reducing the peaks and troughs of drug action) as these drugs induce less nausea, a common side-effect of rapid-acting compounds (19, 50, 98, 194)

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The National Center for Complementary and Integrative Health (NCCIH) acknowledges that certain botanicals studied for glucose management - including berberine, cinnamon extract, and chromium - have published evidence behind them, while consistently noting that evidence quality varies and that most studies involve oral, not transdermal, administration