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An optogenetic stimulation of GLP-1Rs in habenular circuits was also shown to abolish nicotine reward and decrease nicotine intake in mice 109

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GLP-1 restores the intestinal barrier function in DSS-induced colitic mice DSS-induced local and systemic proinflammatory mediators led to the disruption of the intestinal barrier

These check-ups are a bit like the blood draws and body scans in research, which are basic but crucial to advancing safely

This means that while mild to moderate IBS may not prevent Wegovy use, severe gastrointestinal symptoms might warrant caution