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doi: 10.1016/j.peptides.2021.170545

Choice of the second agent to start alongside metformin should be based on the individual's priorities, preferences, and comorbidities [Grade D, Consensus]

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Stay Informed Key dates to watch in 2026: TRIUMPH-1 and TRIUMPH-2 results (mid-2026), head-to-head retatrutide vs tirzepatide results (December 2026), and any NDA filing announcements from Eli Lilly