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The data supports continued use in: Type 2 diabetes Obesity and metabolic syndrome Patients with cardiometabolic risk factors Reasonable caution is still appropriate in individuals with: Active pancreatitis Recurrent idiopathic pancreatitis Severe hypertriglyceridemia until corrected

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Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies