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Its physiological actions include stimulating glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and enhancing satietymechanisms that collectively contribute to glucose lowering and weight reduction

Figure 1 presents a flowchart of the study selection process

[DOI] [PMC free article] [PubMed] [Google Scholar] [8].Damm P, Houshmand-Oeregaard A, Kelstrup L, Lauenborg J, Mathiesen ER, Clausen TD
A novel oral glucagon-like peptide 1 receptor agonist protects against diabetic cardiomyopathy via alleviating cardiac lipotoxicity induced mitochondria dysfunction
Another consideration for GLP-1/GIP/GCG agonists is their potential negative impact on lean mass [32]