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For one, they may allow people with knee osteoarthritis to avoid or delay knee replacement surgery
In this case, the affinity would weaken if Glu was replaced with a lactam bridge because the charge would be dispersed

Lower blood sugar reduces the likelihood of fat storage and promotes better fat metabolism, making it easier to manage weight

[PubMed] [PMC]35

Patients with certain genetic profiles may experience less bloating naturally, or may benefit from personalized dosing strategies that minimize this side effect from the start