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These are not exaggerations from anxious patients

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Formation of Projection Pathways from the Arcuate Nucleus of the Hypothalamus to Hypothalamic Regions Implicated in the Neural Control of Feeding Behavior in Mice

Eli Lilly stock (LLY) popped by more than 5% on Wednesday after the Food and Drug Administration (FDA) approved the company's new weight-loss pill that Eli Lilly says can be taken "any time of day without food or water restrictions." The approval sets up a new phase of competition between Eli Lilly and its main competitor, Danish drugmaker Novo Nordisk (NVO), in the weight-loss drug space

used Cre-lox technology to delete the gene encoding the GLP-1R specifically in the CNS to reveal that GLP-1R agonist-induced weight loss requires GLP-1Rs in the CNS [13]