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One technological solution involves the use of a GRAS strain, Lactobacillus paracasei , engineered to express exenatide

But because the landscape around compounded GLP-1 medications has shifted dramatically since the FDA resolved the semaglutide shortage in February 2025, and what was once a straightforward decision now involves regulatory gray areas, legal battles, and quality control questions that most people never expected to navigate

Its all about making informed choices and being proactive

Overall tolerability of the treatment was good, with the most common side effect being nausea, particularly during treatment initiation or dose adjustments, while diarrhea was reported by 5% of patients, which was dose-dependent and easily managed

Funding This research and manuscript development were funded by Novo Nordisk Pharma Ltd