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In addition to joint symptoms, many people with RA feel tired, feverish, and generally unwell, especially during flare-ups, when symptoms become more intense

A randomized controlled trial involving 70 days of alternate-day fasting (ADF) showed no measurable decline in fat-free mass despite substantial fat loss (109)

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In findings from the STEP TEENS phase 3a trial, adolescents aged 12 to 17 years with obesity or overweight and at least one weight-related coexisting condition were randomly assigned 2:1 to receive semaglutide 2.4 mg (Wegovy, Novo Nordisk) or placebo for 68 weeks