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Caloric restriction leads to high marrow adiposity and low bone mass in growing mice
Novos estimates help bracket the range: Floor (~15%): In early 2025, Novo said ~1M U.S
The additional three percentage points of weight loss from 8mg to 12mg amount to roughly six to eight extra pounds for most people
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Rather than counting every calorie, focus on eating whole foodslean proteins, non-starchy vegetables, healthy fats, and complex carbohydratesin portions that feel satisfying without overeating
