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When the medication slows gastric emptying, the bolus of food that eventually does pass into the small intestine can be partially fermented and osmotically active, drawing water into the intestinal lumen and triggering loose stools or diarrhea

These can include nausea, vomiting, diarrhea, or constipation

10.1161/CIRCRESAHA.121.319874 [DOI] [PMC free article] [PubMed] [Google Scholar] 24

Its the loss of estrogen, progesterone, and metabolic stability

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