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[46] found that T (iNKT) cells, a rare subset of innate T cells that have immune regulatory properties, expressed GLPRs, and that there was a dose-dependent inhibition of GLP-1 on the iNKT cell cytokine secretion of IFN and IL-2

The American Association of Clinical Endocrinology advocates for improved access to these evidence-based therapies, particularly for patients with cardiovascular disease or obesity-related complications where clinical benefits are well-established

Overall, the onset of GI AEs is slightly higher in those trials designed to assess the efficacy and safety of GLP-1 RAs in people with obesity, which may be ascribed to the fact that doses are higher than those used in clinical trials in people with T2D

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They offer a range of substantial benefits, including weight loss, improved blood sugar levels, and reduced cardiovascular disease risk