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This uncertainty drives conservative clinical recommendations
Mekala A, Qiu H
However, having two separate mechanisms active at once introduces cumulative tolerability challenges, especially gastrointestinal side effects that both drugs can independently trigger
Furthermore, those who died during followup could have been misclassified, that is, as nonadherent
Iwasaki H, Kajimura M, Osawa S, Kanaoka S, Furuta T, Ikuma M, et al
