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Aim for 100-150g daily protein to [preserve lean mass during weight loss](/guides/glp1-muscle-loss-prevention-semaglutide-tirzepatide-guide) 6

The findings indicate that increased vigilance is warranted when prescribing exenatide, liraglutide, semaglutide, and tirzepatide to patients aged 45-64, and dulaglutide to patients aged 65 years and older

Cardiovascular event rates don't increase

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Interestingly, in people with type 2 diabetes mellitus, who often exhibit glomerular hyperfiltration, GLP-1 receptor agonists stabilize or modestly reduce eGFR, an effect reminiscent of the initial declines observed with RAAS and SGLT2 inhibitors [64]