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A GLP-1 receptor agonist is a type of medication that stimulates insulin release at high blood glucose levels and suppresses glucagon secretion under low blood glucose conditions

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Acknowledgements We are grateful to all participants and acknowledge the support of the members of the RECAP study who contributed considerably to the data collection

Confirming the metabolic relevance of central GIPR signaling, neuronal loss of GIPR renders mice resistant to GIP-induced body weight loss and GIPR/GLP-1R co-agonism is more potent than selective GLP-1R agonism for weight loss 54

In July of this year, a bill entitled the Treat and Reduce Obesity Act of 2023 was introduced in the Senate with the explicit goal of lifting Medicares coverage exclusion for weight loss products, arguing that obesity increases the risk of multiple chronic conditions and thus costs the government billions of dollars