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Why Oral Tirzepatide Doesnt Exist Yet: Pharmaceutical Challenge: GLP-1 medications like tirzepatide and semaglutide are large peptide molecules that break down quickly in the digestive system

Dehydration: Gastrointestinal side effects can also lead to dehydration, contributing to muscle spasms and eye twitching

Although there are some restrictions on compounders, the FDA does not verify the safety, quality, or effectiveness of compounded drugs

FDA labeling notes that delayed gastric emptying may affect absorption of oral medications and that these agents are not recommended for patients with severe gastroparesis
