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A sweeping Lancet review reveals how modern incretin-based drugs are reshaping treatment for obesity and diabetes, delivering powerful weight loss while simultaneously protecting the heart, kidneys, and metabolic health

They were especially important in identifying cardiovascular effects such as increased heart rate, and assessing gastrointestinal tolerability

Such tests include A1C, fasting glucose, and kidney and liver panels

Keeping it off

Activation of these receptors produces several effects: Appetite suppression: GLP-1 agonists activate anorexigenic (appetite-suppressing) POMC/CART neurons and inhibit orexigenic (appetite-stimulating) NPY/AgRP neurons in the hypothalamus, reducing hunger signaling Enhanced satiety: Activation of brainstem GLP-1 receptors amplifies satiety signals from the gastrointestinal tract, causing patients to feel full earlier and longer after meals Reduced food reward: GLP-1 receptor activation in the mesolimbic dopamine system reduces the hedonic drive to eat, diminishing cravings for high-calorie foods (Blundell et al., Diabetes, Obesity and Metabolism , 2017) Peripheral Effects Beyond central nervous system activity, GLP-1 agonists produce peripheral effects that contribute to weight loss: Delayed gastric emptying: GLP-1 receptor activation in the stomach slows gastric motility, prolonging gastric distension and promoting earlier satiety