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GLP3-R-A Game Changer in Obesity Pharmacotherapy

In the tirzepatide SURMOUNT-4 trial, participants regained approximately 14% of their original body weight within one year of stopping, while those who continued tirzepatide lost an additional 5.5%

Specifically, FBF-1 and FBF-2 (collectively FBF) proteins are 95% identical, and they maintain GSCs by repressing the expression of genes that are associated with germline differentiation, including gld-1 (a KH-motif containing RNA-binding protein) ( gld-2 [a poly(A) polymerase] ( gld-3 (a bicaudal-C homolog) (Figure 1B)

Researchers are continuing to study the best dosing strategies to balance effectiveness with tolerability

Some people respond better to one drug or the other, but we dont know why