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Description
Most of the total weight loss happens in the first 6 to 9 months

Early research suggests this area is worth studying, but retatrutide-specific human evidence is limited

Injection site reactions Redness, mild swelling, or itching at the injection site

FDA labeling states that Zepbound may cause fetal harm and should be discontinued when pregnancy is recognized

Limitations & Considerations The enrolled participants with obesity and overweight may represent a subpopulation with a greater commitment to weight-management efforts than the general population with obesity The measured baseline cardiometabolic risk factors in the trial population, such as blood pressure and lipids, were relatively normal, possibly attenuating the potential to show improvement, though meaningful changes in these variables were observed