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The model, beginning in 2026 for Medicaid and 2027 for Medicare, is voluntary for drug manufacturers, state Medicaid programs, and Medicare Part D plans

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Oxidative stress refers to a state of imbalance between oxidation and antioxidant effects in the body, favoring oxidation, leading to inflammatory infiltration of neutrophils, increased protease secretion, and production of a large number of oxidative intermediates

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