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Once a pen is opened and in use, it can be kept at room temperature (below 30C) or in the fridge for up to 30 days, away from direct sunlight

But the FDA's order clearly means compounders can't make copies based on now-resolved shortages

6 Given that elderly patients are at a higher risk for sarcopenia, it is essential to further investigate how Semaglutide treatment affects skeletal muscle in this population

Population and endpoints A definitive trial would enroll patients with biopsy-confirmed MASH and clinically meaningful fibrosis typically stage F2F3, the range where progression risk and regulatory interest are highest and would be powered against the two histologic endpoints regulators recognize: resolution of steatohepatitis without worsening of fibrosis, and improvement in fibrosis by at least one stage without worsening of steatohepatitis

Head-to-head comparison Direct head-to-head trials are more reliable for comparing the effectiveness, results, and safety profiles