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The primary end point was acomposite of death from cardiovascular causes, myocardialinfarction (MI), or stroke and was tested for noninferiority (noninferiority margin for the hazard ratio, 1.05)

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The net benefit of GLP-1 receptor agonists in adults with overweight or obesity who do not have diabetes depends on their weight loss target and willingness to accept harms, according to researchers.Although GLP-1 receptor agonists have demonstrated effectiveness in reducing weight loss and risks for other chronic diseases, questions remain over whether the benefits outweigh the harms of the

This is nearing the levels obtained by