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Why the question is not "animal or alternative" but "what does each model actually measure?" Stefano Gaburro, PhD The Wrong Question Dominates the Debate The pharmaceutical industry is infatuated with GLP-1 receptor agonists

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And the exercise interaction backs this up: higher fitness builds a greater parasympathetic reserve (essentially, a better ability to slow your heart rate), which helps offset the sympathetic drive from GLP-1