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Challenges Induced by GLP-1 Medications GLP-1 medications have demonstrated effectiveness in achieving significant weight loss and improved glycemic control, but they come with side effects, such as caloric deficit, muscle mass loss, slowed gastric emptying, and gastrointestinal issues, which can complicate long-term health maintenance and potentially undermine the medications success

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10.1016/S0140-6736(16)31679-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 54.Blood Pressure Lowering Treatment Trialists Collaboration

This direct-access approach has allowed tens of thousands of patients to start effective weight loss therapy within days rather than waiting months for insurance decisions

Discovery The development of GLP-1 based drugs for obesity did not happen overnight