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The former tennis star appeared in a commercial for the weight loss drug during the Super Bowl, which did not impress viewers who expected her to announce a comeback

GLP-1 receptor agonists including semaglutide must be stopped before pregnancy due to animal studies showing potential fetal harm

In contrast, pregnancy enhances hormonal crosstalk through placental hormones, triggering metabolic realignments necessary for fetal energy demands

Compared with liraglutide alone, the combined treatment decreased time to complete a stair climb test by 1.2 s [95% confidence interval 0.61.9] (corresponding to 8.6%) and improved peak oxygen consumption by 3.0 mL/min/kg fat-free mass [95% confidence interval 0.55.5]

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