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The risk of elevated semaglutide transfer into milk and infant risk from drug exposure could be elevated during colostral phases
Multi-society clinical practice guidance for the safe use of glucagon-like peptide-1 receptor agonists in the perioperative period

For colorectal cancer, reductions in circulating insulin and systemic inflammation are plausible mechanisms, although further tissue-level validation is needed (Figure 5)

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The dual mechanism also appears to better preserve lean mass during weight loss, which is critically important during menopause when muscle preservation becomes increasingly challenging
