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However, it is uncertain whether those actions directly contribute to the nephroprotective effects of GLP-1 receptor agonists

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Similarly, exendin-4 has been shown to directly increase cAMP activity in these IELs, however, their role in modulating enterocyte function has yet to be fully explored [69]

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There is evidence that suggests GLP-1 medications may lead to improved body composition as the loss of fat mass is often 2-3x greater than the loss of fat free mass

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