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Additionally, the cardiac magnetic resonance substudy of the SUMMIT trial revealed that compared with placebo, tirzepatide treatment of obese HFpEF patients reduced the LV mass and paracardial adipose tissue volume, with the changes in the LV mass paralleling the degree of weight loss [166]

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Theres concern about the safety of different salt formulations, says Diana Isaacs, PharmD, BCADM, CDCES, an endocrinology clinical pharmacy specialist at the Cleveland Clinic Endocrinology and Metabolism Institute in Cleveland

In contrast, long-acting agonists (such as albiglutide or dulaglutide, or extended-release exenetide) have a stronger effect to reduce fasting glucose levels mediated by their effect on insulin and glucagon release