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A collaborative study carried out by the team "Functional Pharmacology and Physiopathology of Membrane Receptors" led by Dr Ralf Jockers, and published in Nature Metab., shows that mutations of the gene encoding the receptor of glucagon-like peptide 1 (GLP1R) affect metabolic traits such as glucose and body weight management and modulates the effectiveness of GLP1R agonists clinically used to treat diabetic and/or obese patients.

Following functional endoscopic sinus surgery, adults with chronic rhinosinusitis with nasal polyps and obesity had a lower risk for revision surgery if they were prescribed a GLP-1 receptor agonist, according to study results.These data were published in Otolaryngology-Head and Neck Surgery.

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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were developed as insulinotropic and anti-hyperglycemic agents for the treatment of type 2 diabetes, but...