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Freezing can damage the protein structure of the medication, rendering it ineffective or potentially harmful

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140 Previous studies have also corroborated our findings, as evidenced by the fact that GLP-1RA may only exert heart action via canonical GLP-1R in atrial but not ventricular myocardium, owing to a lack of canonical GLP-1R expressions in the ventricular myocardium

Jing F, Zou Q, Pu Y (2023) GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model