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However, some known adverse events were increased in SGLT2 inhibitor treatment, such as genital infection, diabetic ketoacidosis, and volume depletion
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The PKC-dependent effect of GLP-1 on membrane depolarization was mediated by activation of Trpm4 and Trpm5, and GLP-1 failed to increase electrical activity and insulin secretion in islets isolated from Trpm4 and Trpm5 KO mice [514]
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