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Evolution and mechanism of action of beta-blockers Types of betablockers: Nonselective betablockers Selective betablockers Betareceptor Location: Heart Positive chronotropic effects (increases heart rate) Positive inotropic effects (increases contractility of the myocardium) Kidney Increased release of renin, which in turn increases blood pressure Betareceptor Location: Smooth muscle cells Promotes relaxation Skeletal muscle cells Promotes tremor and increased glycogenolysis Liver Increases glycogenolysis Betareceptor Location: Adipose tissue Induces lipolysis Administration: intravenous and oral Firstgeneration nonselective betablockers Affect all betareceptors

Mounjaro was originally approved to treat type 2 diabetes, while Zepbound was specifically approved for chronic weight management

After the total study period (8-week low-calorie diet and 1-year intervention phase), the exercise and liraglutide groups showed reduced fat percentage and fat mass, with additive reductions in the combination group (Figure 1B and C)

Due to potential physical and psychological side effects, any GLP-1 use should be medically monitored

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