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Improvements in lipid levels also have been observed during treatment with GLP-1 receptor agonists
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The primary limitation is the lack of a specific FDA approval for adult GHD, which means it has not undergone the large-scale, rigorous clinical trials required for such an indication

This reduction is induced by a decline in the secretion of IL-33 in murine models [135]

In that context, a 16% benefit is a big deal. He notes that these findings were among patients at high risk for a cardiovascular event and may not apply to lower-risk populations

10.1016/j.lfs.2022.121141 28 VillalbaA.Rodriguez-FernandezS.Perna-BarrullD.AmpudiaR