constipation from semaglutide Why Matters While on GLP-1/GIP-1 Medications Constipation is a common and sometimes underappreciated side effect of GLP-1 and GIP-1 agonists like (Wegovy®) or tirzepatide (Zepbound®). Left untreated, it can lead does semaglutide give you constipation
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Staying well-hydrated prevents dehydration-related symptoms, and moderate physical activity like walking can aid digestion
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However, how AMPK regulates GLP-1 signalling pathway needs to be further investigated

The STEP trial programme (which primarily enrolled adults without type 2 diabetes) showed that participants with obesity achieved an average weight loss of approximately 15% of their initial body weight over 68 weeks, compared to 2.4% with placeboall participants also received lifestyle intervention
