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Patients achieved substantial weight loss during the initial GLP-1 RA phase (~1822% at 12 months), which was subsequently maintained after its discontinuation, with total weight reduction reaching 25.5% (95% CI 23.127.9%) at 593 days, with most patients on metformin

Notably, curcumin can enhance methylation at oncogenic promoters like mTOR, increasing DNMT3a/3b expression and suppressing myeloma cell proliferation

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SHBG Studies have suggested that obesity treatment increases SHBG levels from low levels in the obese and overweight state in patients with polycystic ovarian syndrome (PCOS) [40,41]