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Gasoyan added that, in this large observational study of patients who discontinued semaglutide or tirzepatide, reinitiation of the original medication or receipt of alternative obesity treatment was common, which may explain why they regained less weight than patients in randomized trials. Additionally, previous research suggests that GLP-1 drug discontinuation often occurs for practical reasons rather than lack of effectiveness

The medication alone, without the internal work without nervous system regulation, without resonance, without addressing the root patterns leaves people in a kind of pharmacological version of the emotional flatness that food dysfunction itself creates

GLP-1 medicines have revealed a new biological understanding of food noise symptoms

Compared with the initiation of sulfonylurea, the addition of SGLT2is to GLP-1RA therapy was associated with a significantly lower incidence rate of the composite cardiovascular endpoint (9.9 versus 13.0 per 1,000 person-years

However, their wealth of pleiotropic actions soon raised expectations that they might confer benefits on non-metabolic disorders