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When Staying Longer At A Dose Works Better Than Escalating Its a common assumption that increasing the dose is the best way to break a plateau
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The nucleus tractus solitarii projects to multiple regions of the CNS involved in the regulation of appetite, including the hypothalamus, ventral tegmental area, lateral parabrachial nucleus, and nucleus accumbens (58, 59)

( 10.1056/NEJMoa1607141) [DOI] [PubMed] [Google Scholar] Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JFE, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, et al

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