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The law (Medicare Modernization Act of 2003) explicitly excludes drugs when used for weight loss, weight gain, or anorexia. (ASPE) Some proposed changes (including reinterpreting the exclusion for obesity) were considered , but in April 2025 those were not finalized

This hormonal imbalance can also cause metabolic complications

2.4 Metabolicreproductive psychological axis: multifaceted pathways of GLP-1RA action Building on Figure 1B, we discuss four non-mutually exclusive routes by which GLP-1RAs may contribute to reproductive improvement in PCOS: (i) metabolic mediation, (ii) central neuroendocrine modulation, (iii) attenuation of lipotoxicity/inflammation, and (iv) psychological and behavioral facilitation

This complexity is further echoed in analyses that differentiate between disease stages

Dhurandhar EJ et al
