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Acknowledgements The authors thank Edson Fernandes de Assis for performing the cytokine assays with the multiplex platform and the Fiocruz network of technological platforms and the confocal platform from the Oswaldo Cruz Foundation, Fiocruz, Rio de JaneiroManguinhos Mar campus

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This increase is generally clinically insignificant in healthy individuals but should be monitored in patients with pre-existing cardiac conditions

If your study isolates GLP-1 receptor-mediated mechanisms specifically insulin secretion dynamics, glucagon suppression, gastric motility, or satiety signaling through vagal afferents Semaglutide gives you a clean single-receptor signal without GIP receptor involvement

However, semaglutide therapy is also associated with concerning adverse effects like acute pancreatitis, anesthetic risks like pulmonary aspiration or residual gastric content, acute kidney injury, acute gallbladder injury, nonarteritic anterior ischemic optic neuropathy and diabetic retinopathy